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Class I and class II major histocompatibility molecules play a role in bone marrow–derived macrophage development
Author(s) -
Armstrong Jason W.,
Simske Steven J.,
Beharka Alison A.,
Balch Signe,
Luttges Marvin W.,
Chapes Stephen K.
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.55.5.658
Subject(s) - biology , major histocompatibility complex , macrophage , mhc class ii , immunology , immune system , mhc class i , bone marrow , secretion , microbiology and biotechnology , endocrinology , genetics , in vitro
Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI‐ and MHCII‐deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony‐stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development J. Leukoc. Biol. 55: 658–661; 1994.