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Cloning and expression of the chicken CD18 cDNA
Author(s) -
Bilsland Caroline A. G.,
Springer Timothy A.
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.55.4.501
Subject(s) - biology , cloning (programming) , complementary dna , microbiology and biotechnology , molecular cloning , genetics , computational biology , gene , computer science , programming language
The leukocyte integrins play a critical role in a number of cellular adhesive interactions during the immune response. We describe here the isolation and characterization of the chicken β 2 (CD18) subunit, common to the leukocyte integrin family. The deduced 748‐amino‐acid sequence reveals a transmembrane protein with 65% and 64% identity with its human and murine homo‐logues, respectively. The chicken β 2 can associate on the cell surface with the human α subunit of LFA‐1 and yields a hybrid molecule capable of binding to purified ICAM‐1 and ICAM‐3. J. Leukoc. Biol. 55: 501–506; 1994.
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