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Macrophages and angiogenesis
Author(s) -
Sunderkötter Cord,
Steinbrink Kerstin,
Goebeler Matthias,
Bhardwaj Ranjit,
Sorg Clemens
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.55.3.410
Subject(s) - angiogenesis , biology , thrombospondin 1 , microbiology and biotechnology , proteases , macrophage , extracellular matrix , tumor necrosis factor alpha , immunology , in vivo , in vitro , cancer research , biochemistry , enzyme
Macrophages are supposed to play a key role in inflammatory and tumor angiogenesis. Their importance derives from (1) their ubiquitous presence in normal and especially inflamed tissues, (2) their potential to become activated in response to appropriate stimuli, and (3) their repertoire of secretory products. By release of proteases, growth factors (bFGF, GM‐CSF, TGF‐α, IGF‐I, PDGF, VEGF/VPF, TGF‐ β ), and other monokines (IL‐1, IL‐6, IL‐8, TNF‐α, substance P, prostaglandins, interferons, thrombospondin 1), activated macrophages have the capability to influence each phase of the angiogenic process, such as alterations of the local extracellular matrix, induction of endothelial cells to migrate or proliferate, and inhibition of vascular growth with formation of differentiated capillaries. This review describes macrophage physiology and the influence of macrophage secretory products on the different phases of angiogenesis in vitro and in vivo. J. Lcukoc. Biol . 55: 410–422; 1994.