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Transforming growth factor β : a matter of life and death
Author(s) -
McCartneyFrancis Nancy L.,
Wahl Sharon M.
Publication year - 1994
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.55.3.401
Subject(s) - biology , transforming growth factor , microbiology and biotechnology , homeostasis , function (biology) , transgene , immune system , genetically modified mouse , neuroscience , immunology , genetics , gene
A wide variety of functions, many of which represent opposing activities, have been attributed to TGF‐ β , a molecule implicated in embryogenesis, development, and immune and inflammatory processes. This paradoxical behavior of promoting or inhibiting cell growth and function, while important in normal physiology and homeostasis, can contribute to or interrupt pathologic sequelae, making TGF‐ β a particularly intriguing molecule for study. New transgenic mouse models displaying targeted alterations in TGF‐ β 1 expression offer novel and unique opportunities to determine the essential function(s) of TGF‐ β . J. Leukoc. Biol. 55: 401–409; 1994.