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Involvement of inflammatory mediators in macrophage antitumor activity
Author(s) -
Bonta Ivan L,
BenEfraim Shlomo
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.54.6.613
Subject(s) - biology , macrophage , immunology , inflammation , cancer research , in vitro , genetics
This review describes the potential role of macrophages in defense against cancer cells and the regulatory involvement of inflammatory mediators in this role. Interactions between macrophage‐derived cytokines (tumor necrosis factor a, interleukin‐1, IL‐6) and their interrelationships with eicosanoids (mainly the cyclooxygenase product prostaglandin E 2 and some lipoxygenase metabolites) represent a network that controls the expression of antitumor activity of macrophages either in a cell‐to‐cell contact system between the effector and the target tumor cell or as cell‐free soluble products. Attention is given to the influence of tumor burden on production of cytokines and eicosanoids by macrophages and to the production of these mediators by tumor cells. Emphasis is placed on the roles of TNF‐α and PGE 2 in links between inflammatory and antitumor functions of macrophages. Finally, the perspectives and still existing problems in clinical implications of macrophage‐derived cytokines are discussed in terms of a conceivable macrophage‐directed immunotherapy of cancer.