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Chemokines and serpentines: the molecular biology of chemokine receptors
Author(s) -
Kelvin David J.,
Michiel Dennis F.,
Johnston James A.,
Lloyd Andrew R.,
Sprenger Hans,
Oppenheim Joost J.,
Wang JiMing
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.54.6.604
Subject(s) - chemokine receptor , biology , receptor , chemokine , ccr1 , chemotaxis , microbiology and biotechnology , ccl7 , ccr3 , cc chemokine receptors , ccl21 , chemokine receptor ccr5 , c c chemokine receptor type 6 , biochemistry
Chemokines are pro‐inflammatory molecules with a diverse array of biological and biochemical functions. These molecules induce the migration of a number of leukocyte subsets including monocytes, neutrophils, and T‐cells. The recent cloning of the IL‐8, GRO, and MIP‐lα chemokine receptors revealed that these glycoproteins belong to the serpentine family of seven transmembrane G‐protein‐coupled receptors. Other members of this family include die chemotactic receptors for fMLP and C5a, indicating that a common pathway for eliciting the directional migration of leukocytes is probably transduced via G proteins. Ligand binding to chemokine receptors is complex, featured by multiple chemokines binding to a single receptor and multiple receptors binding a specific ligand. Future directions in this field appear to be focused on the cloning of novel receptors and the identification of ligands for orphaned receptors.