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Dietary supplementation with n‐3 fatty acids suppresses interleukin‐2 production and mononuclear cell proliferation
Author(s) -
Endres Stefan,
Meydani Simin N.,
Ghorbani Reza,
Schindler Ralf,
Dinarello Charles A.
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.54.6.599
Subject(s) - biology , peripheral blood mononuclear cell , cell growth , interleukin 2 , interleukin , immunology , cytokine , medicine , endocrinology , food science , biochemistry , in vitro
We studied the in vitro production of interleukin‐2 in nine healthy volunteers who added 18 g/day of fish‐oil concentrate rich in n‐3 polyunsaturated fatty acids to their normal Western diet for a period of 6 weeks. Interleukin‐2 synthesis from stimulated peripheral blood mononuclear ceils was suppressed from 6.2 ng/ml at baseline to 2.2 ng/ml 10 weeks after the end of n‐3 fatty acid supplementation (65% decrease; P ‐ .04). At the same time phytohemagglutinin‐induced proliferation of mononuclear cells was suppressed by 70% from the presupplement level. Interleukin‐2 production returned to the premedication level at the end of the studies. The results suggest that the effect of dietary n‐3 fatty acids in some diseases may be mediated in part by decreased production of interleukin‐2 and decreased mononuclear cell proliferation.