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Soluble FCγ receptors
Author(s) -
Fridman Wolf H.,
Teillaud JeanLuc,
Bouchard Caroline,
Teillaud Christophe,
Astier Anne,
Tartour Eric,
Galon Jerome,
Mathiot Claire,
Sautes Catherine
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.54.5.504
Subject(s) - receptor , biology , transmembrane protein , cell surface receptor , antibody , microbiology and biotechnology , cleavage (geology) , immunology , biochemistry , paleontology , fracture (geology)
Soluble FCγ receptors have been identified in biological fluids of mice and humans. They are produced either by alternative splicing of the exon encoding the transmembrane region of the receptor (FcγRII) or by proteolytic cleavage at the cell membrane (FCγRII and FC7RIII). They inhibit B cell proliferation and immunoglobulin production. Their concentrations in plasma seem to be modified during the development of certain diseases, as for instance in multiple myeloma, where plasma concentrations oi soluble FCγKIll are correlated with the stage of the disease.