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Inflammation, immunoregulation, and inducible nitric oxide synthase
Author(s) -
Nussler Andreas K.,
Billiar Timothy R.
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.54.2.171
Subject(s) - biology , nitric oxide , inflammation , mediator , nitric oxide synthase , pathophysiology , nos1 , microbiology and biotechnology , immunity , immunology , function (biology) , immune system , neuroscience , endocrinology
Abstract Nitric oxide (NO), the molecule of the year 1992, is gaining recognition as an important biological mediator. Its multitude of physiologic and pathophysiologic functions result from both a wide distribution of synthesis and diverse mechanisms of action. Besides its functions as a potent vasodilator and neurotransmitter, NO is important in inflammation and immunity. Both beneficial and detrimental consequences of induced synthesis have been discovered. Information is now accumulating on the regulation and function of induced NO. The recent cloning of human inducible NO cDNA should assist in defining the role of inducible NO in human physiology and pathophysiology.