Stimulation of the bactericidal activity of polymorphonuclear leukocytes by manganese | Zendy

Klebanoff Seymour J. | Zendy; Schlechte Kristie G. | Zendy; Waltersdorph Ann M. | Zendy

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Stimulation of the bactericidal activity of polymorphonuclear leukocytes by manganese

Author(s) -

Klebanoff Seymour J.,

Schlechte Kristie G.,

Waltersdorph Ann M.

Publication year - 1993

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.53.6.666

Subject(s) - biology , stimulation , microbiology and biotechnology , manganese , immunology , neuroscience , chemistry , organic chemistry

An antioxidant effect of manganese (Mn) complexes due to the scavenging of the superoxide anion (Of) or to the decomposition of hydrogen peroxide (H 2 O 2 ) has been described. We report here that Mn also can exert a prooxidant effect under certain experimental conditions. Thus Mn 2+ in phosphate buffer increased the bactericidal effect of phorbol myristate acetate‐stimulated polymorphonuclear leukocytes (PMNs) on extracellular Escherichia coli. This effect was inhibited by azide, catalase, and a decrease in chloride concentration and was not observed when normal PMNs were replaced by those of patients with chronic granulomatous disease or myeloperoxidase (MPO) deficiency. Mn 2+ could be replaced by Mn 3+ or by superoxide dismutase (SOD). These findings suggest that Mn (or SOD), by increasing the conversion of Of to H 2 O 2 , can increase the activity of the MPO‐H 2 O 2 ‐chloride antimicrobial system released by stimulated PMNs.

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