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Immunotherapy of tularemia: characterization of a monoclonal antibody reactive with Francisella tularensis
Author(s) -
Narayanan R.B.,
Drabick Joseph J.,
Williams Jim C.,
Fortier Anne H.,
Meltzer Monte S.,
Sadoff Jerald C.,
Bolt Christopher R.,
Nacy Carol A.
Publication year - 1993
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.53.1.112
Subject(s) - francisella tularensis , tularemia , monoclonal antibody , biology , antigen , virology , microbiology and biotechnology , agglutination (biology) , antibody , western blot , immunology , virulence , biochemistry , gene
An IgM monoclonal antibody (mAb) recognized surface antigens specific to Francisella tularensis wild‐type (Schu4) and live vaccine strain (LVS), and reacted with both in ELISA and slide agglutination tests. This mAb also reacted with LVS microorganisms in tissues of infected mice as assessed by an indirect fluorescence technique. Western blot analysis showed the mAb to react with antigens associated with F. tularensis LPS.