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Effects of antiorthostatic suspension and corticosterone on macrophage and spleen cell function
Author(s) -
Kopydlowski Karen M.,
McVey D. Scott,
Woods Keith M.,
Landolo John J.,
Chapes Stephen K.
Publication year - 1992
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.52.2.202
Subject(s) - corticosterone , macrophage , biology , concanavalin a , spleen , tumor necrosis factor alpha , cytotoxicity , endocrinology , medicine , immunology , biochemistry , in vitro , hormone
The purpose of this study was to determine whether antiorthostatic suspension of C3HeB/FeJ mice for a period of 11 days affected macrophage and spleen cell function. We found that antiorthostatic suspension did not alter macrophage secretion of prostaglandin E 2 , tumor necrosis factor α, and interleukin‐1. Antiorthostatic suspension also did not affect macrophage‐mediated contact‐dependent cytotoxicity, TNF‐mediated cytotoxicity, expression of class II histocompatibility molecules, or concanavalin A and Bandeiraea simplicifolia lectin binding sites. The proliferative response of splenic T cells in response to mitogens and staphylococcal exotoxins was significantly enhanced in antiorthostatically suspended mice. We detected significantly higher concentrations of corticosterone in the plasma of antiorthostatically suspended mice. Therefore, there did not appear to be any direct immunosuppressive effects of corticosterone on the parameters tested.