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Mouse macrophages contain a truncated CD4 transcript
Author(s) -
Moore Steven C.,
Anderson Stephen J.,
Walker William S.
Publication year - 1992
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.52.1.128
Subject(s) - biology , microbiology and biotechnology , genetics
Mouse macrophages do not express CD4 on their surfaces. We used the polymerase chain reaction to investigate CD4 gene transcription in individual clones of primary mouse splenic macrophages and cell lines of spleen and bone marrow macrophages. The results show only the presence of CD4 mRNA transcripts that are truncated in the 3′ coding sequence, thus explaining the lack of expression of a mature CD4 gene product by these cells.