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Interferon α‐induced changes in Fc γ R‐specific mRNA expression and isotype‐specific, Fc γ R‐mediated phagocytosis in C3H/OuJ ( Lps n ) and C3H/HeJ ( Lps d ) macrophages
Author(s) -
Fultz Marion J.,
Vogel Stefanie N.
Publication year - 1992
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.51.3.300
Subject(s) - phagocytosis , biology , isotype , interferon , messenger rna , immunology , macrophage , microbiology and biotechnology , antibody , gene , in vitro , biochemistry , monoclonal antibody
Peritoneal exudate macrophages from C3H/OuJ ( Lps n ) and C3H/HeJ ( Lps d ) mice were treated with interferon α (IFN‐α), and isotype‐specific phagocytosis and gene expression were measured. IFN‐α selectively augments phagocytosis of IgG2a, with a highly significant induction of Fc γ RI mRNA expression, while parallel Fc γ RIIIα measurements show a relatively small increase.