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Differential production of granulocyte‐macrophage colony‐stimulating factor by macrophages from mice susceptible and resistant to Leishmania mexicana amazonensis
Author(s) -
Soares Luis Roberto B.,
Barcinski Marcello A.
Publication year - 1992
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.51.3.220
Subject(s) - leishmania mexicana , biology , macrophage , granulocyte macrophage colony stimulating factor , cytokine , granulocyte , microbiology and biotechnology , immunology , leishmania , bone marrow , in vitro , parasite hosting , genetics , world wide web , computer science
The present results demonstrate that macrophages from mice susceptible to infection with Leishmania mexicana amazonensis sustain a higher production of granulocyte‐macrophage colony‐stimulating factor (GM‐GSF) throughout the in vitro infection than macrophages from a resistant strain. Resident macrophages from BALB/c and C57B1/10 mice were infected with promastigotes of L. mexicana amazonensis and the amount of biologically active GM‐CSF was measured in the supernatants collected at different times of infection. Measurements were made by bone marrow and GM‐CSF/interleukin‐3 addicted cell proliferation. Because GM‐GSF is a disease‐exacerbating cytokine, its differential production by infected macrophages may be one of the mechanisms defining resistance or susceptibility to a leishmanial infection.