Premium
Determination of the Number and Distribution of Macrophages, Lymphocytes, and Granulocytes in the Mouse Uterus From Mating Through Implantation
Author(s) -
De Mamata,
Choudhuri Rajani,
Wood Gary W.
Publication year - 1991
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.50.3.252
Subject(s) - biology , uterus , mating , granulocyte , andrology , immunology , distribution (mathematics) , microbiology and biotechnology , phagocytosis , zoology , genetics , medicine , mathematical analysis , mathematics
The concentration and distribution of F4‐80 positive cells (macrophages) and common leukocyte antigen (CLA) positive (bone marrow derived) cells were assessed in mouse uterus between days 1 and 8 of pregnancy. High numbers of polymorphonuclear leukocytes and lymphocytes were present on days 1 and 2, but not thereafter. Granulocytes were found both in the endometrium and within the luminal epithelium. The percentage of total cells contributed by macrophages was high on days 1 and 2. That percentage decreased significantly on day 3, then increased again on day 5 and remained high through day 8. Macrophages always were found in myometrial stroma. Macrophages were found throughout the endometrium on days 2 through 8. High numbers of macrophages were observed near epithelia, particularly on days 1,2,4, and 5. Few F4‐80 + or CLA + cells were observed within the developing primary and secondary decidua. The results demonstrate that an inflammation‐like cellular response occurs in the uterus following mating and that macrophages are a major cellular component of the uterus during early pregnancy.