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Effects of Corticosterone and Microgravity on Inflammatory Cell Production of Superoxide
Author(s) -
Fleming Sherry D.,
Edelman Linda S.,
Chapes Stephen K.
Publication year - 1991
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.50.1.69
Subject(s) - superoxide , biology , corticosterone , inflammation , immunology , microbiology and biotechnology , endocrinology , biochemistry , enzyme , hormone
In this investigation we studied the effects of corticosterone and microgravity on Propionibacterium acnes‐induced inflammatory cells ability to produce superoxide (O 2 ‐ ). We found in vitro and in vivo exposure of murine peritoneal inflammatory cells to corticosterone did not inhibit the O 2 ‐ response. We also found that in microgravity P . acnes‐induced inflammatory cells were capable of producing four times as much O 2 ‐ as at 1g. Therefore, neither corticosterone nor microgravity experienced during parabolic flight prevents an O 2 ‐ response by inflammatory cells.