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The interplay between neutrophils and microbiota in cancer
Author(s) -
Smith Carolyne K.,
Trinchieri Giorgio
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.4ri0418-151r
Subject(s) - granulopoiesis , biology , cancer , immunology , compartment (ship) , neutrophil extracellular traps , cancer research , inflammation , genetics , haematopoiesis , stem cell , oceanography , geology
The role of the microbiota in many diseases including cancer has gained increasing attention. Paired with this is our expanding appreciation for the heterogeneity of the neutrophil compartment regarding surface marker expression and functionality. In this review, we will discuss the influence of the microbiota on granulopoiesis and consequent activity of neutrophils in cancer. As evidence for this microbiota‐neutrophil‐cancer axis builds, it exposes new therapeutic targets to improve a cancer patient's outcome.