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Eosinophils in fungal diseases: An overview
Author(s) -
Figueiredo Rodrigo T.,
Neves Josiane S.
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.4mr1117-473r
Subject(s) - immunology , biology , eosinophil , aspergillus fumigatus , asthma , candida albicans , allergy , allergic bronchopulmonary aspergillosis , effector , alternaria alternata , immunopathology , immunoglobulin e , microbiology and biotechnology , antibody , botany
Abstract Eosinophils are the prominent cells in asthma, allergic bronchopulmonary mycosis (ABPMs), and fungal‐sensitization‐associated asthma, but their roles in the immunopathology of these disorders are not well understood. Moreover, the immunological mechanisms underlying the molecular direct effector interactions between fungi and eosinophils are rare and not fully known. Here, we provide an overview of eosinophil contributions to allergic asthma and ABPMs. We also revise the major general mechanisms of fungal recognition by eosinophils and consider past and recent advances in our understanding of the molecular mechanisms associated with eosinophil innate effector responses to different fungal species relevant to ABPMs ( Alternaria alternata, Candida albicans , and Aspergillus fumigatus ). We further examine and speculate about the therapeutic relevance of these findings in fungus‐associated allergic pulmonary diseases.