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Identification of key signaling pathways induced by SARS‐CoV2 that underlie thrombosis and vascular injury in COVID‐19 patients
Author(s) -
Maxwell Anthony J.,
Ding Jiahui,
You Yuan,
Dong Zhong,
Chehade Hussein,
Alvero Ayesha,
Mor Yechiel,
Draghici Sorin,
Mor Gil
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.4covr0920-552rr
Subject(s) - biology , covid-19 , identification (biology) , thrombosis , signal transduction , key (lock) , coronavirus , immunology , virology , neuroscience , pathology , genetics , medicine , disease , infectious disease (medical specialty) , ecology , botany , outbreak
The SARS‐CoV‐2 pandemic has led to hundreds of thousands of deaths and billions of dollars in economic damage. The immune response elicited from this virus is poorly understood. An alarming number of cases have arisen where COVID‐19 patients develop complications on top of the symptoms already associated with SARS, such as thrombosis, injuries of vascular system, kidney, and liver, as well as Kawasaki disease. In this review, a bioinformatics approach was used to elucidate the immune response triggered by SARS‐CoV‐2 infection in primary human lung epithelial and transformed human lung alveolar. Additionally, examined the potential mechanism behind several complications that have been associated with COVID‐19 and determined that a specific cytokine storm is leading to excessive neutrophil recruitment. These neutrophils are directly leading to thrombosis, organ damage, and complement activation via neutrophil extracellular trap release.