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Antimicrobial zinc toxicity in Mϕs: ZnT1 pays the toll
Author(s) -
Neyrolles Olivier
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.4ce0520-256r
Subject(s) - zinc , biology , escherichia coli , transporter , phagosome , intracellular , tlr4 , antimicrobial , microbiology and biotechnology , toll , zinc toxicity , toxicity , biochemistry , gene , chemistry , immunology , receptor , organic chemistry
Abstract Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB , Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contributes to zinc accumulation in Escherichia coli ‐containing phagosomes, resulting in increased bacterial clearance.