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PDZ proteins are expressed and regulated in antigen‐presenting cells and are targets of influenza A virus
Author(s) -
Barreda Dante,
SánchezGalindo Marisa,
LópezFlores Jessica,
NavaCastro Karen E.,
Bobadilla Karen,
SalgadoAguayo Alfonso,
SantosMendoza Teresa
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.4ab0517-184r
Subject(s) - pdz domain , biology , microbiology and biotechnology , innate immune system , antigen , antigen presentation , cell polarity , immune system , cell , t cell , immunology , genetics
In this work, we identified the expression, regulation, and viral targeting of Scribble and Dlg1 in antigen‐presenting cells. Scribble and Dlg1 belong to the family of PDZ (postsynaptic density ( P SD95), disc large ( D lg), and zonula occludens ( Z O‐1)) proteins involved in cell polarity. The relevance of PDZ proteins in cellular functions is reinforced by the fact that many viruses interfere with host PDZ‐dependent interactions affecting cellular mechanisms thus favoring viral replication. The functions of Scribble and Dlg have been widely studied in polarized cells such as epithelial and neuron cells. However, within the cells of the immune system, their functions have been described only in T and B lymphocytes. Here we demonstrated that Scribble and Dlg1 are differentially expressed during antigen‐presenting cell differentiation and dendritic cell maturation. While both Scribble and Dlg1 seem to participate in distinct dendritic cell functions, both are targeted by the viral protein NS1 of influenza A in a PDZ‐dependent manner in dendritic cells. Our findings suggest that these proteins might be involved in the mechanisms of innate immunity and/or antigen processing and presentation that can be hijacked by viral pathogens.