Recombinant Interleukin‐4 Enhances the Chemiluminescent Oxidative Burst of Murine Peritoneal Macrophages | Zendy

Tan Henkie P. | Zendy; NehlsenCannarella Sandra L. | Zendy; Garberoglio Carlos A. | Zendy; Tosk Jeffrey M. | Zendy

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Recombinant Interleukin‐4 Enhances the Chemiluminescent Oxidative Burst of Murine Peritoneal Macrophages

Author(s) -

Tan Henkie P.,

NehlsenCannarella Sandra L.,

Garberoglio Carlos A.,

Tosk Jeffrey M.

Publication year - 1991

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.49.6.587

Subject(s) - respiratory burst , monoclonal antibody , biology , recombinant dna , oxidative stress , chemiluminescence , macrophage , microbiology and biotechnology , cytokine , stimulation , oxidative phosphorylation , cell culture , respiratory system , immunology , antibody , biochemistry , chemistry , endocrinology , in vitro , anatomy , genetics , gene , organic chemistry

We evaluated the effects of murine recombinant interleukin‐4 (rIL‐4) on murine peritoneal macrophages. We showed a marked, dose‐dependent stimulation of respiratory oxidative burst by IL‐4 in peptone‐elicited murine peritoneal macrophages. This effect was abolished by a neutralizing monoclonal antibody (mAb) to rlL‐4 confirming that the enhanced chemiluminescence was due to IL‐4. In contrast, rlL‐4 depressed the respiratory oxidative burst of a transformed murine macrophage cell line, J774, in a dose‐dependent mAb‐reversible manner.

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