Inflammatory Responses to Cryptococcosis in Congenitally Athymic Mice | Zendy

Salkowski Cindy A. | Zendy; Balish Edward | Zendy

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Inflammatory Responses to Cryptococcosis in Congenitally Athymic Mice

Author(s) -

Salkowski Cindy A.,

Balish Edward

Publication year - 1991

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.49.6.533

Subject(s) - cryptococcus neoformans , cryptococcosis , histopathology , biology , immunology , inflammation , microbiology and biotechnology , ratón , pathology , medicine

Histopathology revealed that nu/nu mice developed both acute and chronic inflammatory responses following infection with Cryptococcus neoformans. In comparison to inflammatory responses in nu/+ mice, the responses in nu/nu mice were delayed, less intense, contained predominantly more polymorphonuclear leukocytes (PMNs) than macrophages (Mφs), and did not develop into granulomas. In addition, nu/nu mice developed cryptococcal skin lesions demonstrating that C. neoformans is dermatotropic in a T‐cell deficient host. Quantitative culturing of infected organs confirmed that delayed and incomplete inflammatory responses observed in nu/nu mice correlated with their enhanced susceptibility to C. neoformans .

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