Intracellular pH Regulates the Production of Different Oxygen Metabolites in Neutrophils: Effects of Organic Acids Produced by Anaerobic Bacteria | Zendy

Tonetti Maurizio | Zendy; Cavallero Annalisa | Zendy; Botta Giuseppe A. | Zendy; Niederman Richard | Zendy; Eftimiadi Costantino | Zendy

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Intracellular pH Regulates the Production of Different Oxygen Metabolites in Neutrophils: Effects of Organic Acids Produced by Anaerobic Bacteria

Author(s) -

Tonetti Maurizio,

Cavallero Annalisa,

Botta Giuseppe A.,

Niederman Richard,

Eftimiadi Costantino

Publication year - 1991

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.49.2.180

Subject(s) - biology , bacteria , intracellular , anaerobic exercise , microbiology and biotechnology , oxygen , biochemistry , anaerobic bacteria , reactive oxygen species , physiology , chemistry , organic chemistry , genetics

The effects of short chain carboxylic acids (SCCA), namely succinic, butyric, and iso‐butyric, on neutrophil metabolic activation were assessed. SCCA induced a significant decrease in O 2 ‐ recovery and chemlluminescent response in neutrophils activated with the diacylglycerol analog tetradecanoyl‐phorbol‐acetate (TPA). SCCA did not alter O 2 consumption, H 2 O 2 production, or the calorimetrically determined energy expenditure occurring during the metabolic burst. SCCA also induced a significant acidification of intracellular pH (pH i ). These results are consistent with an increased divalent versus univalent O 2 reduction performed by the NADPH oxidase at a more acidic intracellular pH.

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