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Differential Production of IFN‐α/β by CSF‐1‐ and GM‐CSF‐Derived Macrophages
Author(s) -
Falk Lydia A.,
Vogel Stefanie N.
Publication year - 1990
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.48.1.43
Subject(s) - biology , vesicular stomatitis virus , macrophage , granulocyte macrophage colony stimulating factor , bone marrow , progenitor cell , immunology , granulocyte , colony stimulating factor , haematopoiesis , granulocyte macrophage colony stimulating factor receptor , in vitro , virus , microbiology and biotechnology , cytokine , macrophage colony stimulating factor , stem cell , biochemistry
Mature macrophages, derived in vitro from bone marrow progenitors under the influence of either macrophage colony stimulating factor (CSF‐1) or granulocyte‐macrophage (GM)‐CSF, have been shown to differ morphologically and functionally. The data presented in this report demonstrate that macrophages derived from bone marrow progenitors under the influence of CSF‐1 are highly resistant to infection with vesicular stomatitis virus (VSV), and that this refractoriness can be reversed by treatment of cells with anti‐IFN‐α/β antibody. In contrast, macrophages derived from bone marrow progenitors under the influence of GM‐CSF are highly susceptible to the cytopathic effects of VSV, but can be protected by very low concentrations of exogenous IFN‐α/β. These findings suggest that CSF‐1 derived macrophages have a greater capacity for the production and/or utilization of IFN‐α/β than GM‐CSF‐derived macrophages, which may account for many of the differentiative differences reported previously.