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Antigen Presentation by the CD4 Positive Monocyte Subset
Author(s) -
Szabo G.,
Miller C.L.,
Kodys K.
Publication year - 1990
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.47.2.111
Subject(s) - biology , antigen presentation , monocyte , immunology , microbiology and biotechnology , antigen , t cell , immune system
Although CD4 antigen is expressed on monocytes (MØ), its functional role is uncharacterized. In this study, isolated human MØ were separated into CD4 + and CD4 ‐ MØ subsets and assessed for presentation of tetanus toxoid. The CD4 ‐ MØ subset had decreased antigen presenting cell (APC) capacity as well as increased PGE 2 production when compared to the CD4 + MØ subset. Addition of a cyclo‐oxygenase inhibitor (Indo‐methacin) did not restore the CD4 ‐ MØ subset's APC capacity to that of the similarly treated CD4 + MØ subset, eliminating differential PGE 2 production as the primary cause of differential APC capacity. Production of monokines such as IL‐1 and plasminogen activator, which affect APC capacity, was similar in the CD4 MØ subsets. However, tumor necrosis factor (TNF) production (IFNγ plus MDP‐induced) of the CD4 + MØ subset was slightly greater than that of the CD4 ‐ MØ. CD4 ‐ MØ's lower APC capacity is not totally explained by their differential IL‐1, TNF, or PGE 2 production.