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Mitochondrial Biogenesis During the Activation of Lymphocytes by Mitogens: The Immunosuppressive Action of Tetracyclines
Author(s) -
Van den Bogert C.,
Melis T.E.,
Kroon A.M.
Publication year - 1989
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.46.2.128
Subject(s) - biology , mitochondrial biogenesis , action (physics) , microbiology and biotechnology , mitochondrion , immunology , lymphocyte activation , immune system , t cell , physics , quantum mechanics
The role of mitochondrial biogenesis and function during mitogenic stimulation of rat thymocytes was investigated. The results show that mitochondrial biogenesis is required to provide the ATP for the energy‐requiring processes occurring during blastogenesis. Impairment of mitochondrial biogenesis by inhibition of mitochondrial protein synthesis inhibits blast transformation. Since the tetracyclines impair mitochondrial protein synthesis, the results offer an explanation for the well‐known immunosuppressive effects of these antibiotics.