Premium
Thermal Regulation of FMLP Receptors on Human Neutrophils
Author(s) -
Coles Rosalind B.,
Ranney Richard R.,
Freer Richard J.,
Carchman Richard A.
Publication year - 1989
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.45.6.529
Subject(s) - receptor , chemotaxis , biology , medicine , endocrinology , neutrophile , microbiology and biotechnology , biochemistry , immunology , inflammation
Polymorphonuclear leukocytes (PMNs) from subjects diagnosed as having iuvenile periodontitis (JP) have been categorized on the basis of their chemotactic (CTX) response to f‐met‐leu‐phe (FMLP) when assayed concurrently with PMNs from periodon‐tally healthy subjects (HP). When PMNs from JP groups demonstrating depressed CTX were assayed for lysosomal enzyme secretion (LES) in response to FMLP, there were no significant differences with respect to rate or amount. Significant differences were observed between HP and chemotactically depressed JP cells when assessed for FMLP receptor ligand binding at 23°, but not at 4°. Receptor differences observed at 23° in HP cells included an increase in amount of total binding, number of receptors, and available dispiaceable binding sites, compared with the chemotactically depressed JP PMNs, whereas the receptor affinities were similar. These data suggest that differences in FMLP receptor density in JP PMN that are chemotactically depressed may be related to processes that modulate receptor mobility and/or expression.