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Both Recombinant Interleukin‐1 (Beta) and Purified Human Monocyte Interleukin‐1 Prime Human Neutrophils for Increased Oxidative Activity and Promote Neutrophil Spreading
Author(s) -
Sullivan Gail W.,
Carper Holliday T.,
Sullivan James A.,
Murata Teizo,
Mandell Gerald L.
Publication year - 1989
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.45.5.389
Subject(s) - biology , beta (programming language) , monocyte , immunology , recombinant dna , respiratory burst , interleukin , prime (order theory) , interleukin 8 , inflammation , cytokine , biochemistry , gene , computer science , programming language , mathematics , combinatorics
Both purified human monocyte interleukin‐1 and recombinant interleukin‐1 (beta) primed neutrophils for increased superoxide production and chemiluminescence in response to f‐met‐leu‐phe. In addition, purified human monocyte interleukin‐1 and recombinant interleukin‐1 (beta) altered neutrophil shape. Recombinant interleukin‐1 (alpha) used at the same concentration of interleukin‐1 (beta) did not prime neutrophils for increased superoxide production after stimulation with f‐met‐leu‐phe. interleukin‐1 expressed by monocytes in response to endotoxin stimulation could act as a modulator of neutrophil function.