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Induction of Continuous I‐A Expression by Murine Peritoneal Macrophages: Lack of Correlation With T Cell Responses of Bcg r and Bcg s Mice
Author(s) -
Kwasniewski Michael N.,
Zwilling Bruce S.
Publication year - 1988
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.44.3.192
Subject(s) - biology , in vitro , microbiology and biotechnology , recombinant dna , t lymphocyte , macrophage , interferon gamma , immunology , gene , biochemistry
The induction of continuous I‐A expression by L3T4 and Lyt2 lymphocyte subpopulations from Bcg r and Bcg s mice was compared. We found that the induction of continuous I‐A expression was independent of the Bcg geneotype of the T cells. T cells from congenie Beg s BALB/c mice and C.D2Bcg r mice could not induce continuous I‐A expression in vitro and were deficient in their ability to produce IFN‐gamma in vitro. In contrast, T cells from other strains of Bcg r and Bcg s mice could induce continuous I‐A expression. Both recombinant IL‐2 and IL‐4 acted synergistically with low levels of IFN‐gamma to induce continuous I‐A expression by macrophages from Bcg r mice.