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Effect of Lead on Macrophage Function
Author(s) -
Kowolenko Michael,
Tracy Leigh,
Mudzinski Stanley,
Lawrence David A.
Publication year - 1988
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.43.4.357
Subject(s) - phagocytosis , biology , macrophage , immune system , antigen , in vivo , in vitro , antigen presentation , peritoneal cavity , immunology , inducer , microbiology and biotechnology , t cell , biochemistry , gene , anatomy
Lead (Pb) has been shown to alter various parameters of immune function such as host resistance and antibody formation. In addition, various heavy metals have been implicated as inducers of autoimmunity. In these experiments, macrophages, isolated from the peritoneal cavity of mice exposed to various doses of lead in vivo as well as cells exposed in vitro were tested for the following immunologic parameters: phagocytosis, antigen presentation, interleukin 1 production, and their ability to stimulate the autologous mixed lymphocyte reaction (AMLR). The results obtained indicate that Pb appears to alter the ability of macrophages to present antigen by enhancing the AMLR while having no effect on phagocytosis or IL‐1 production. These data suggest that Pb may interfere with antigen‐specific interactions between macrophages and T cells.