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Low‐Density Lipoprotein Oxidized by Polymorphonuclear Leukocytes Inhibits Natural Killer Cell Activity
Author(s) -
Tanabe Fuminori,
Sato Akihiko,
Ito Masahiko,
Ishida Eiko,
Ogata Masahiro,
Shigeta Shiro
Publication year - 1988
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.43.3.204
Subject(s) - biology , low density lipoprotein , immunology , natural killer cell , lipoprotein , cell , granulocyte , microbiology and biotechnology , biochemistry , cholesterol , cytotoxicity , in vitro
We studied the effect of low‐density lipoprotein (LDL) oxidized by opsonized zymosan‐stimulated polymorphonuclear leukocytes (PMN) on natural killer (NK) cell activity. Oxidized LDL inhibited NK cell activity in a dose‐dependent manner, whereas normal LDL left it unaffected. However, oxidized LDL did not inhibit antibody‐dependent cell‐mediated cytotoxicity (ADCC). Moreover, a positive correlation was observed between the amount of thiobarbituric acid‐reacting substances (TBARS) on the sample of oxidized LDL and the degree of inhibition of NK cell activity. We also showed that oxidized LDL suppressed the binding capacity of purified large granular lymphocytes (LGL) to target cells without changing the lytic activity. These results therefore suggest that activated PMN can modulate NK cell activity by oxidizing LDL.