Characterization of Surface Markers of Continuously Growing Murine Resident Macrophages | Zendy

Muller Christian D. | Zendy; Lombard Yves | Zendy; Bartholeyns Jacques | Zendy; Poindron Philippe | Zendy; Schuber Francis | Zendy

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Characterization of Surface Markers of Continuously Growing Murine Resident Macrophages

Author(s) -

Muller Christian D.,

Lombard Yves,

Bartholeyns Jacques,

Poindron Philippe,

Schuber Francis

Publication year - 1988

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.43.2.165

Subject(s) - biology , phagocytosis , mannose receptor , receptor , macrophage , in vitro , antigen , microbiology and biotechnology , spleen , bovine serum albumin , fc receptor , mannose , immunology , biochemistry

Conditions have been described which allow an in vitro indefinite multiplication of differentiated murine macrophages (Lombard et al: Biol Cell 53, 219, 1985). R. and MAY‐1 ceil lines, which were obtained, respectively, from mouse (Balb/c) spleen and resident peritoneal macrophages, have been further characterized. They present at their surface, besides the Mac‐1 antigen and Fc‐receptor, a mannose receptor which was characterized for its binding properties. This receptor Is responsive for a specific phagocytosis of mannosylated particles, i.e., mannosylated latex beads or oil droplets containing mannosylated bovine serum albumin. Moreover, R and MAY‐1 ceils present an ectoenzyme profile (NAD + glycohydrolase and nucleotide pyrophosphatase) similar to those of the corresponding resident macrophages.

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