Influence of Heparin and a Low Molecular Weight Heparin Fraction of the Leukocytes in an Experimental Venous Thrombosis Model | Zendy

Doutremepuich C. | Zendy; Toulemonde F. | Zendy; Seze O. | Zendy; Pereira F. | Zendy; Anne M.C. | Zendy; Doutremepuich F. | Zendy

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Influence of Heparin and a Low Molecular Weight Heparin Fraction of the Leukocytes in an Experimental Venous Thrombosis Model

Author(s) -

Doutremepuich C.,

Toulemonde F.,

Seze O.,

Pereira F.,

Anne M.C.,

Doutremepuich F.

Publication year - 1987

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.42.6.628

Subject(s) - heparin , ligature , thrombosis , dose , thrombus , biology , venous thrombosis , pharmacology , peripheral blood mononuclear cell , ligation , immunology , medicine , in vitro , biochemistry , microbiology and biotechnology

A randomized study was performed to observe the effects induced by heparin and a low molecular weight heparin fraction (at different dosages) on the leukocytes of rats in the presence of experimental venous thrombosis. The experimentation was carried out on two series of animals: the first with a ligature of the inferior vena cava inducing the formation of a thrombus, the second without any ligature. The results show that the induction of thrombosis involves: in the blood, an increase of the number leukocytes, principally polymorphonuclear cells; in the thrombi, a significant rise in the total count of leukocytes, here mononuclear cells; the latter number increases with the dosages of the administered drugs.

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