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Influence of Heparin and a Low Molecular Weight Heparin Fraction of the Leukocytes in an Experimental Venous Thrombosis Model
Author(s) -
Doutremepuich C.,
Toulemonde F.,
Seze O.,
Pereira F.,
Anne M.C.,
Doutremepuich F.
Publication year - 1987
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.42.6.628
Subject(s) - heparin , ligature , thrombosis , dose , thrombus , biology , venous thrombosis , pharmacology , peripheral blood mononuclear cell , ligation , immunology , medicine , in vitro , biochemistry , microbiology and biotechnology
A randomized study was performed to observe the effects induced by heparin and a low molecular weight heparin fraction (at different dosages) on the leukocytes of rats in the presence of experimental venous thrombosis. The experimentation was carried out on two series of animals: the first with a ligature of the inferior vena cava inducing the formation of a thrombus, the second without any ligature. The results show that the induction of thrombosis involves: in the blood, an increase of the number leukocytes, principally polymorphonuclear cells; in the thrombi, a significant rise in the total count of leukocytes, here mononuclear cells; the latter number increases with the dosages of the administered drugs.