Premium
Self‐Renewal of Pulmonary Alveolar Macrophages: Evidence From Radiation Chimera Studies
Author(s) -
Tarling John D.,
Lin Hsiusan,
Hsu Shin
Publication year - 1987
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.42.5.443
Subject(s) - chimera (genetics) , biology , alveolar macrophage , immunology , population , macrophage , pulmonary alveolus , lung , mitosis , stem cell , microbiology and biotechnology , genetics , medicine , in vitro , environmental health , gene
Radiation‐induced chimeric mice were used to study the origin of pulmonary alveolar macrophages. Unlike in other studies, these radiation chimeras were prepared by using a special fractionated irradiation regimen to minimize the killing of alveolar macrophage colony‐forming cells, putative local stem cells. For this study CBA mice with or without T6 chromosome marker were used. Under this experimental condition, the majority of alveolar macrophages in mitosis are of host origin even after 45 weeks. These data suggest that alveolar macrophages are a self‐renewing population under normal steady‐state conditions.