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Selective Recognition of Rat Follicular Dendritic Cells (Dendritic Reticulum Cells) by a New Monoclonal Antibody Ki‐M4R In Vitro and In Vivo
Author(s) -
Wacker H.H.,
Radzun H.J.,
Mielke V.,
Parwaresch M.R.
Publication year - 1987
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.41.1.70
Subject(s) - follicular dendritic cells , germinal center , biology , monoclonal antibody , dendritic cell , in vivo , microbiology and biotechnology , immunogen , cd40 , antibody , in vitro , lymphatic system , pathology , immune system , immunology , antigen presenting cell , b cell , t cell , cytotoxic t cell , medicine , biochemistry
Abstract Using unstimulated rat peritoneal cells as immunogen a new monoclonal antibody KiM4R was produced. Ki‐M4R recognizes follicular dendritic cells (dendritic reticulum cells) in germinal centers of lymphoid follicles in lymphatic tissue. In addition, sinus lining cells, endothelia of postcapillary venules, as well as mesangial cells of the renal glomerula immunoreact with Ki‐M4R in vitro as well as in vivo. This antibody might be useful for studying the interaction of follicular dendritic cells and B‐cell immune response.