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Modulation of Macrophage I‐A Expression: Lack of Effect of Prostaglandins and Glucocorticoids on Macrophages That Continuously Express I‐A
Author(s) -
Vespa Linda,
Johnson Sarah C.,
Aldrich Wayne A.,
Zwilling Bruce S.
Publication year - 1987
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.41.1.47
Subject(s) - biology , macrophage , microbiology and biotechnology , expression (computer science) , gene expression , modulation (music) , immunology , gene , genetics , in vitro , philosophy , computer science , programming language , aesthetics
The ability of prostaglandins, glucocorticoids and lipopolysaccharide to modulate I‐A expression on macrophages that continuously or transiently express I‐A was compared. We found that neither prostaglandins nor glucocorticoids affected I‐A expression by macrophages that continuously expressed I‐A. In contrast, prostaglandin E 2 (PGE 2 ) inhibited the lymphokine‐induced maintenance of I‐A on macrophages that transiently expressed I‐A while glucocorticoids inhibited both the induction and expression of I‐A. Lipopolysaccharide caused a loss in the expression of Class II molecules on macrophages that continuously expressed l‐A by a prostaglandin‐independent mechanism. The lack of effect of PGE 2 and glucocorticoids may be related to our observation that continuous expression of I‐A does not require its continued synthesis.