Partial Characterization of a Mitomycin‐C Resistant T Cell | Zendy

Anderson Robert E. | Zendy; Standefer Jimmy C. | Zendy; Troup Gary M. | Zendy; Pogue Laura E. | Zendy

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Partial Characterization of a Mitomycin‐C Resistant T Cell

Author(s) -

Anderson Robert E.,

Standefer Jimmy C.,

Troup Gary M.,

Pogue Laura E.

Publication year - 1987

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1002/jlb.41.1.33

Subject(s) - biology , mitomycin c , characterization (materials science) , microbiology and biotechnology , genetics , nanotechnology , materials science

A cell resistant to concentrations of mitomycin‐C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiosensitive. In part, the resistance of this T cell appears to relate to a reduced activity of a microsomal reductase responsible for converting mitomycin‐C to its more active form. Discrepancies in reductase activity may represent a way to differentiate among subsets of lymphocytes.

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