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Partial Characterization of a Mitomycin‐C Resistant T Cell
Author(s) -
Anderson Robert E.,
Standefer Jimmy C.,
Troup Gary M.,
Pogue Laura E.
Publication year - 1987
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.41.1.33
Subject(s) - biology , mitomycin c , characterization (materials science) , microbiology and biotechnology , genetics , nanotechnology , materials science
A cell resistant to concentrations of mitomycin‐C associated with the inactivation of many in vitro immune responses is described. This cell is responsive to concanavalin A (Con A), poorly adherent to nylon wool, present in relatively greater numbers in lymph node than other lymphoid tissues, and is relatively radiosensitive. In part, the resistance of this T cell appears to relate to a reduced activity of a microsomal reductase responsible for converting mitomycin‐C to its more active form. Discrepancies in reductase activity may represent a way to differentiate among subsets of lymphocytes.