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Alveolar and lung interstitial macrophages: Definitions, functions, and roles in lung fibrosis
Author(s) -
Shi Ting,
Denney Laura,
An Huazhang,
Ho LingPei,
Zheng Yuejuan
Publication year - 2021
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3ru0720-418r
Subject(s) - lung , biology , homeostasis , immune system , immunology , innate immune system , pulmonary fibrosis , fibrosis , microbiology and biotechnology , pathology , medicine
Mϕs are the main innate immune cells in the lung at homeostasis, with important roles in host defence and immune modulation. Alveolar Mϕs (AMs) and interstitial Mϕs (IMs) are the two lung Mϕ subsets, so called according to the sites they reside in. These subsets are also defined by their origins and immunological microenvironment, which endow these cells with distinct features and plasticity. This review summarizes the latest definitions and functions of lung Mϕs during homeostasis and provides exemplar of their divergent roles in lung fibrosis.