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PPAR‐γ in innate and adaptive lung immunity
Author(s) -
Nobs Samuel Philip,
Kopf Manfred
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3mr0118-034r
Subject(s) - lung , biology , immunology , acquired immune system , innate immune system , immunity , priming (agriculture) , transcription factor , inflammation , immune system , peroxisome proliferator activated receptor , receptor , medicine , biochemistry , botany , germination , gene
Abstract The transcription factor PPAR‐γ (peroxisome proliferator‐activated receptor‐γ) is a key regulator of lung immunity exhibiting multiple cell type specific roles in controlling development and function of the lung immune system. It is strictly required for the generation of alveolar macrophages by controlling differentiation of fetal lung monocyte precursors. Furthermore, it plays an important role in lung allergic inflammation by licensing lung dendritic cell t helper 2 (Th2) priming capacity as well as acting as a master transcription factor for pathogenic Th2 cells. Due to this plethora of functions and its involvement in multiple pulmonary diseases including asthma and pulmonary alveolar proteinosis, understanding the role of PPAR‐γ in lung immunity is an important subject of ongoing research.