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Regulation of leukocyte function by citric acid cycle intermediates
Author(s) -
Patil Naeem K.,
Bohan Julia K.,
Hernandez Antonio,
Patil Tazeen K.,
Sherwood Edward R.
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3mir1118-415r
Subject(s) - biology , function (biology) , citric acid , citric acid cycle , microbiology and biotechnology , biochemistry , immunology , metabolism
Cellular metabolism is a means of generating ATP to provide energy for key cellular functions. However, recent research shows that citric acid cycle intermediates target vital cellular functions of the innate immune system. Succinate, itaconate, citrate, and fumarate have been shown to mediate or regulate important myeloid cell functions during infection and inflammation. This review covers the regulatory functions of citric acid cycle intermediates in myeloid cells and discusses potential translational applications, key mechanistic questions, and future research directions.