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miRNA regulation of innate immunity
Author(s) -
MomenHeravi Fatemeh,
Bala Shashi
Publication year - 2018
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3mir1117-459r
Subject(s) - biology , innate immune system , microrna , acquired immune system , immunity , immune system , phenotype , autoimmunity , regulation of gene expression , innate lymphoid cell , immunology , gene , computational biology , genetics
MicroRNAs (miRNAs) are small noncoding RNA and are pivotal posttranscriptional regulators of both innate and adaptive immunity. They act by regulating the expression of multiple immune genes, thus, are the important elements to the complex immune regulatory network. Deregulated expression of specific miRNAs can lead to potential autoimmunity, immune tolerance, hyper‐inflammatory phenotype, and cancer initiation and progression. In this review, we discuss the contributory pathways and mechanisms by which several miRNAs influence the development of innate immunity and fine‐tune immune response. Moreover, we discuss the consequence of deregulated miRNAs and their pathogenic implications.