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Inflammasomes in the pathophysiology of autoinflammatory syndromes
Author(s) -
Tartey Sarang,
Kanneganti ThirumalaDevi
Publication year - 2020
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3mir0919-191r
Subject(s) - familial mediterranean fever , inflammasome , nalp3 , pyrin domain , innate immune system , immunology , inflammation , biology , rheumatoid arthritis , immune system , arthritis , pathophysiology , autoimmunity , medicine , disease , pathology , endocrinology
Inflammasomes are a specialized group of intracellular sensors that are key components of the host innate immune system. Autoinflammatory diseases are disorders of the innate immune system that are characterized by recurrent inflammation and serious complications. Dysregulation of the inflammasome is associated with the onset and progression of several autoinflammatory and autoimmune diseases, including cryopyrin‐associated periodic fever syndrome, familial Mediterranean fever, rheumatoid arthritis, and systemic lupus erythematosus. In this review, we discuss the involvement of various inflammasome components in the regulation of autoinflammatory disorders and describe the manifestations of these autoinflammatory diseases caused by inflammasome activation.