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Identification of a regulatory Vδ1 gamma delta T cell subpopulation expressing CD73 in human breast cancer
Author(s) -
Chabab Ghita,
Barjon Clément,
Abdellaoui Naoill,
SalvadorPrince Lucie,
Dejou Cécile,
Michaud HenriAlexandre,
BoissièreMichot Florence,
LopezCrapez Evelyne,
Jacot William,
Pourquier Didier,
Bonnefoy Nathalie,
Lafont Virginie
Publication year - 2020
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3ma0420-278rr
Subject(s) - biology , immune system , tumor microenvironment , cancer research , breast cancer , population , immunology , cancer , t cell , medicine , genetics , environmental health
γδ T cells contribute to the immune response against many cancers, notably through their powerful effector functions that lead to the elimination of tumor cells and the recruitment of other immune cells. However, their presence in the tumor microenvironment has been associated with poor prognosis in breast, colon, and pancreatic cancer, suggesting that γδ T cells may also display pro‐tumor activities. Here, we identified in blood from healthy donors a subpopulation of Vδ1T cells that represents around 20% of the whole Vδ1 population, expresses CD73, and displays immunosuppressive phenotype and functions (i.e., production of immunosuppressive molecules, such as IL‐10, adenosine, and the chemotactic factor IL‐8, and inhibition of αβ T cell proliferation). We then found that in human breast tumors, γδ T cells were present particularly in late stage breast cancer samples, and that ∼20% of tumor‐infiltrating γδ T cells expressed CD73. Taken together, these results suggest that regulatory γδ T cells are present in the breast cancer microenvironment and may display immunosuppressive functions through the production of immunosuppressive molecules, such as IL‐10, IL‐8, and adenosine, thus promoting tumor growth.