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Connecting the dots in type 1 diabetes: The role for gut–pancreas axis
Author(s) -
MenezesSilva Luisa,
Fonseca Denise Morais da
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3ce0719-242r
Subject(s) - nod , biology , nod mice , inflammation , type 1 diabetes , gut flora , immunology , diabetes mellitus , pancreas , autoimmunity , type 2 diabetes , oral tolerance , endocrinology , antigen , immune system
Discussion on changes in gut microbiota driving the breakdown of mucosal barrier in NOD mice; the resulting inflammation and impairment of oral tolerance induces the autoimmune diabetes.