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CD56 − CD16 + NK cells from HIV‐infected individuals negatively regulate IFN‐γ production by autologous CD8 + T cells
Author(s) -
Ma Meichen,
Yin Xiaowan,
Zhao Xue,
Guo Chenxi,
Zhu Xiaoyu,
Liu Tingting,
Yang Mei,
Zhang Zining,
Fu Yajing,
Liu Jing,
Xu Junjie,
Ding Haibo,
Han Xiaoxu,
Chu Zhenxing,
Shang Hong,
Jiang Yongjun
Publication year - 2019
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.3a0819-171rr
Subject(s) - cd16 , biology , interleukin 21 , cd8 , interleukin 12 , immunology , cytotoxic t cell , immune system , interferon gamma , janus kinase 3 , cd3 , in vitro , biochemistry
The percentage of human CD56 − CD16 + NK cells increases during chronic infection with human HIV; however, the biologic role of CD56 − CD16 + NK cells in HIV infection is unclear. Our results demonstrate that the percentage of CD56 − CD16 + NK cells producing IL‐10 and TGF‐β was higher than CD56 dim CD16 + NK cells. CD56 − CD16 + NK cells could inhibit IFN‐γ production by autologous CD8 + T cells, and this inhibition could be partially reversed by anti‐IL‐10, anti‐TGF‐β, or anti‐PD‐L1 mAbs. CD56 − CD16 + NK cells are potential targets for the development of novel immune therapies against HIV infection.