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Cellular Immune Functions of Adults Treated With a Daily, Long‐Term, Low Dose of 13‐cis Retinoic Acid
Author(s) -
Watson Ronald Ross,
Jackson J.C.,
Alberts David S.,
Hicks Mary Jane
Publication year - 1986
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.39.5.567
Subject(s) - retinoic acid , immune system , biology , medicine , retinoid , endocrinology , tretinoin , antigen , antibody , immunology , cell culture , genetics
The effects of long‐term consumption of 13‐ cis retinoic acid (13‐cRA) on cellular immune functions were measured in young, adult volunteers. The retinoid was administered for 9 months at about 0.13 mg/kg/day. The mean 8AM concentrations of 13‐cRA ranged between 30 and 60 ng/ml of serum throughout the study. Corticosteroid levels in plasma decreased significantly throughout treatment, declining from 15.2 ug/dL to 9.1 mg/dL (p < 0.05). T‐cell mitogenesis stimulated by PHA or A Con A was not significantly affected, although this parameter was slightly depressed during the first 2 months of treatment. The percentage of B‐lymphocytes tended to decrease during treatment and returned to normal after cessation of 13‐cRA (p < 0.05), while the percentage of T‐cells as measured by E‐rosette and by fluorescent antibody tagging of surface antigens did not change. The percentage of non T‐cells tended to increase slightly during treatment.