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Fibronectin and Complement Secretion By Monocytes and Peritoneal Macrophages In Vitro From Patients Undergoing Continuous Ambulatory Peritoneal Dialysis
Author(s) -
Goldstein Carl S.,
Garrick Renee E.,
Polin Richard A.,
Gerdes Jeffrey S.,
Kolski Gerald B.,
Neilson Eric G.,
Douglas Steven D.
Publication year - 1986
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.39.4.457
Subject(s) - fibronectin , continuous ambulatory peritoneal dialysis , in vitro , peritonitis , peritoneal dialysis , secretion , opsonin , biology , medicine , in vivo , immunology , peritoneum , endocrinology , phagocytosis , pathology , biochemistry , extracellular matrix , microbiology and biotechnology
We investigated the role of the opsonic glycoprotein fibronectin in the host defense of the peritoneum in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). Fibronectin concentration in peritoneal dialysate from hight infection rate CAPD patients (>1.50 episodes peritonitis per year) was significantly less than from low infection rate CAPD patients (<0.55 episodes peritonitis per year). In vitro secretion of fibronectin by cultured peritoneal macrophages from patients with high infection rate was less than from low infection rate patients (P < 0.05) and controls (P < 0.01). In vitro secretion of the second component of complement, however, was similar in both high and low infection rate patients. Plasma fibronectin concentration and in vitro fibronectin secretion by cultured peripheral blood monocytes was not different between high infection rate patients and low infection rate patients, but was less than normals. Decreased fibronectin secretion by peritoneal macrophages is associated with a higher incidence of peritonitis among CAPD patients.