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Effects of Selenium In Vitro on Human T‐Lymphocyte Functions and K‐562 Tumor Cell Growth
Author(s) -
Watson Ronald Ross,
Moriguchi Satoru,
McRae Bart,
Tobin Lucia,
Mayberry J. Carter,
Lucas David
Publication year - 1986
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1002/jlb.39.4.447
Subject(s) - biology , in vitro , selenium , t lymphocyte , microbiology and biotechnology , lymphocyte , cancer research , lymphocyte subsets , immunology , immune system , t cell , biochemistry , chemistry , organic chemistry
In vitro E‐rosette formation, lymphocyte mitogenesis, and natural killer (NK) cell activity of human blood lymphocytes were strongly inhibited by high concentrations (10 −4 M) of sodium selenite, sodium selenate, and selenium dioxide. Lower concentrations (10 −5 or 10 −7 M) also inhibited E‐rosette formation and natural killer cell activity against K‐562 tumor cells. Lymphocyte transformation induced by concanavalin A (con A) or pokeweed mitogen (PWM) was also inhibited by all selenium compounds tested, but only at the highest concentrations (10 −5 and 10 −4 M). There was depression of the total number of viable lymphocytes following incubation with selenium dioxide only at a high concentration (10 −4 M). Interferon production was enhanced at lower levels (10 −9 to 10 −6 M) of selenium dioxide while a higher concentration (10 −5 and 10 −4 M) appeared to inhibit its production. The mechanism of inhibition by selenium compounds (10 −4 M) is due, in part, to the decrease of viable lymphocytes. It is unclear how other and lower concentrations (10 −7 or 10 −9 M) of selenium compounds inhibit E‐rosette formation, NK activity, or K‐562 tumor cell growth.